Most often, the side effect is temporary and subsides in a few days.
Skin irritation usually manifests in the form of redness or skin discoloration and itching. Itching and hair loss at the site of application have also been reported in some dogs. There are also side effects that have at times been seen to be neurological or mental in nature.Īn immediate reaction your dog could have following the application of the medication is skin irritation. If side-effects occur following the use of Frontline Plus for dogs, they would generally be related to effects on the skin. Although side effects to this medication are not common, they do at times occur and are mostly related to the alcohol that is used as a solvent.įrontline Plus for Dogs: Side Effects to Look For This is because fipronil accumulates in the animal’s sebaceous glands, from where it is consistently released onto the skin and coat.įrontline Plus for dogs is a safe medication to use and can be used on puppies and kittens as early as two days after birth. Once applied, this medication can be effective for a whole month, even if you bathe your dog or take it for a swim. Apart from this, Frontline Plus is also preferred by many due to its long-lasting effect. This medication is known to have 100% efficacy within the first 48 hours of application. Its active ingredients, S-methoprene and fipronil, act to not only kill all existing ticks and fleas but also work on flea eggs and larvae to make sure that they do not mature into adults. Frontline Plus for dogs is topical medication that works against tick and flea infestations.